The Effect of Creatine Supplementation with Resistance Training on the Levels of Renin and Aldosterone in Wistar Rats

Objective: The aim of the present study was to compare the effect of creatine 2% and 5% supplementation with resistance training on the levels of renin and aldosterone

Methods: The 60 Wistar rats were randomly assigned to six groups (resistance training, creatine 2% and creatine 5%, resistance training plus creatine 2% supplementation, resistance training plus creatine 5% supplementation, control). The training included 8 weeks and 5 sessions a week climbing a 1-meter ladder with 26 rungs with 2-cm distances. The One – way analysis of variance (ANOVA) test was used for comparing the variables between groups and LSD test was used for pair-wise comparisons.

Results: There was no significant difference between mean differences of renin level in different groups compared to the control group. Butthere was a significant difference between mean difference of aldosterone level in creatine 5% groups and control group as well as between resistance training plus creatine 2% and creatine 5% groups (p < 0.05). Also, there was significant difference between mean difference of aldosterone level in resistance training and creatine 5% groups (p < 0.05).

Conclusion: As regard to result of the present study consumption of creatine 2% and 5% supplementation may be useful and safe for human so further studies is suggested.