Protein Aggregation A Review

Protein aggregation is arguably the most common and troubling manifestation of protein instability, encountered in almost all stage of protein drug development. Protein generally will tend to aggregate under variety of conditions. The extent of aggregation depends on many factors that can be classified as intrinsic (primary, secondary, tertiary or quaternary structure) and extrinsic (environment in which protein present or processed). These protein aggregate may exhibit less desirable characteristics like reduce or no biological activity. Although a variety of method has been used to inhibit protein aggregation, it involved structural (internal) and environmental (external) modifications.