In Vitro Antioxidant Properties of Novel Schiff Base Complexes

Aim: In order to identify and evaluate the metal-derived synthetic antioxidants having high free radicals scavenging capacity related to various disorders has received much interest in last decades. Recently, synthetic antioxidants are widely used instead of natural antioxidants because they are effective and cheaper.

Study Design: In the current investigation, a synthesized Schiff base ligand (2-{(E)-[(4-chlorophenyl)imino]methyl}phenol) and their metal complexes (Bis(2-{(E)[(4chlorophenyl) imino]methyl} phenol)nickel(II), Bis(2-{(E)[(4chlorophenyl)imino]methyl}phenol)Cobalt(II), Bis(2-{(E)[(4chlorophenyl)imino]methyl}phenol)copper(II), Bis(2-{(E)-[(4-chlorophenyl)imino]methyl}phenol) zinc(II)) have been evaluated in vitro for their possible antioxidant properties.

Place and Duration of Study: Department of chemistry, Abdul Wali Khan University Mardan, Khyber Pakhtunkhwa, Pakistan. The experiment lasted for three days (72 hours).

Methodology: The antioxidant activity of the synthesized compounds were screened by using 2,2-diphenyl-1-picrylhydrazyl (DPPH), Ferrous ion chelation (FIC), Ferric reducing antioxidant power (FRAP), Total antioxidant activity (Phosphomolybdenum methods) and Hydroxyl radical (•OH) radical scavenging activity.

Results: The synthesized compounds showed significant dose dependent antioxidant activities comparable with that of the classical antioxidants, ascorbic acid and ethylenediaminetetraacetic acid (EDTA).

Conclusions: The compounds exhibited are very reactive towards DPPH radicals, OH radicals, and Fe+2 ions and it also actively reduces Fe(III) ion to Fe(II) and Mo(VI) ion to Mo(V) form. The ligand having moderate and all of the metal complexes were existed encouraging results which indicate the importance of Schiff base ligand a metal complexes as a source of synthetic antioxidants and possibly potent drugs.