Intestinal Dysbiosis in Systemic Inflamation and Possibilities of Its Correction with Probiotics

Aims: To estimate intestinal microbial changes and study the efficacy of probiotic preparations in systemic inflammation.

Study Design: Cohort design.

Place and Duration of Study: Sumy State University, Medical Institute. Department of Microbiology and Clinical Immunology, Kharkiv Medical Academy of Postgraduate Education.

Methodology: The study involved 162 patient with chronic infections various sites, including 58 (35.8%) patients with respiratory tract infections, 56 (34.6%) patients with infections of the genitourinary system, and 48 (29.6%) - with purulent inflammatory postoperative complications. We studied the quantitative and qualitative composition of intestinal microflora on the background correction of probiotic preparations.

Results: We have found quantitative and qualitative changes of intestinal microflora in all patients with chronic infections. Dysbiotic changes manifested in reducing the number of major orders symbionts (Lactobacillus spp., Bifidobacterium spp, Escherichia coli with normal enzymatic properties) and increase the number of pathogenic microorganisms (Staphylococcus aureus, Clostridium spp., Candida spp.). In all study groups after using probiotics, the number of pathogenic microorganisms (S. aureus, S. saprophyticus, S. epidermidis, C. albicans, and Cl. perfringens) were decreased and tended to restore normal range of microbial landscape.

Conclusion: So, dysbiotic disorders of the intestine in patients with chronic inflammation characterized by decrease in the number of basic gut symbionts and reducing its protective properties that accompanied the advent of pathogenic microorganisms. In our study probiotics demonstrated statistically significant improvements in the qualitative and quantitative composition of microflora.