Synthesis, Characterization and Complexation Behaviour of Chloroquine towards Ti (II) Ion

Aims: Chloroquine is a member of the drug class 4-aminoquinoline used for the prevention and treatment of malaria in areas where malaria is known to be sensitive to its effects.

Our aim is to synthesize the chloroquine – titanium complex and to study its coordination behavior.

Place and Duration of Study: Department of Chemistry, Michael Okpara University of Agriculture, Umudike, 2019.

Methodology: Ti(II) complex of chloroquine was synthesized by the reaction of chloroquine phosphate with titanium(IV) oxide. The metal complex was characterized based on UV, IR and 1H NMR Spectroscopy.

Results: The UV spectrum of the complex suggested intra ligand charge transfer (ILCT), ligand to metal charge transfer (LMCT), and d-d transition. The IR spectrum of the complex showed the involvement of amine and imine group in coordination to Ti. This showed that chloroquine acted as a bidentate ligand. 1H NMR of the spectrum further showed the involvement of the amine group in coordination.

Conclusion: The ability of chloroquine to sequestrate Ti (II) ion has been assured. This drug can be used to chelate Ti ions from solution, environment, and biological system.