Changes of biochemical parameters of blood serum in subchronic influence of nitric oxide in the experiment

The aim of this work was to study basic biochemical parameters of blood serum in experimental animals in subchronic influence of nitric oxide (NO). The experiments were performed on Wistar rats. The animals were divided into 4 groups: control (intact healthy rats) and three experimental, in which the animals within 30 days were receiving the inhalation of gaseous NO at a concentration of 20, 50 and 100 ppm. The gas mixture was synthesized by the apparatus for generating nitric oxide developed at Sarov. Determination of biochemical parameters of blood serum was performed on an automatic analyzer «ILAB 650» (Italy, USA, Japan). It was shown that subchronic inhalation of NO in all the studied concentrations contribute to the increase of glucose, the activity of aspartate aminotransferase and alkaline phosphatase.